The Quad Screen, sometimes referred to as the Triple Screen or maternal serum screening, is a second-trimester blood test that offers insights into the estimated risk for specific genetic conditions and neural tube defects. It's an optional screening tool that can provide you with more information as you navigate your pregnancy.
What it is
This screening measures the levels of four specific markers in your blood: alpha-fetoprotein (AFP), human chorionic gonadotropin (hCG), unconjugated estriol, and inhibin-A. These four markers, when analyzed together, help estimate the likelihood of your baby having certain conditions. Specifically, the Quad Screen is designed to assess the risk for Down syndrome (Trisomy 21), Trisomy 18, and neural tube defects.
While newer screening options like NIPT (Non-Invasive Prenatal Testing) have largely become the preferred method for Down syndrome screening due to their higher detection rates, the Quad Screen still plays a valuable role. It's particularly useful for screening for neural tube defects, such as spina bifida, where a high AFP level can be an indicator. For some, it might also be a more accessible option if NIPT is not covered by insurance, as it is generally less expensive.
